反应详情

A crude solution of XV (36 g), 10% palladium on carbon (1.80 g), 5 mL of concentrated HCl and 125 mL of MeOH was shaken on a Parr apparatus under 55.5 psig of hydrogen at 22° C. for 3 d. The reaction was filtered over Celite, and concentrated to a residue. This material was partitioned between ether and water. The organic solution was dried (MgSO4), filtered, and concentrated to yield 29.34 g of XVI as a light yellow oil which was carried forward without further purification. The structure was supported by MS and 1H NMR.

1. filtrationThe reaction was filtered over Celite
2. concentrationconcentrated to a residue
3. customThis material was partitioned between ether and water
4. dry with materialThe organic solution was dried (MgSO4)
5. filtrationfiltered
6. concentrationconcentrated