反应详情

A mixture of dibromoethane (10.73 g, 77 mmol) and cetyltrimethylammonium bromide (0.291 g, 0.8 mmol) in 5 cm3 of water is brought to reflux. A solution of 3-methoxycatechol (5 g, 35.7 mmol) in 20N sodium hydroxide (NaOH, 4 g in 5 cm3 of water) is added slowly. The mixture is stirred at the reflux for 12 hours and then, after cooling and extraction with ether, purification on a silica column (eluent: petroleum ether/ether, 9:1) enables 7.4 g of a colorless oil to be isolated

1. temperatureto reflux
2. temperaturereflux for 12 hours
3. temperatureafter cooling
4. extractionextraction
5. customwith ether, purification on a silica column (eluent: petroleum ether/ether, 9:1)
6. customto be isolated