反应详情

2,6-Dimethyl-4-nitrophenyl trifluoromethanesulfonate (8.54 g) and 3.63 g of lithium chloride in 40 ml DMF are heated at 150° for four hours. Solvent is then evaporated, the residue stirred with water and ethyl acetate, filtered, and the filtrate separated. The ethyl acetate is then dried, filtered and stripped, and the residue chromatographed on silica gel with 98:2 hexane:ethyl acetate, affording 4-chloro-3,5-dimethyl-nitrobenzene. NMR (CDCl3): δ2.5 (6H,s), 7.9 (2H,s).

1. customSolvent is then evaporated
2. filtrationfiltered
3. customthe filtrate separated
4. dry with materialThe ethyl acetate is then dried
5. filtrationfiltered
6. customthe residue chromatographed on silica gel with 98:2 hexane