2,2,3,3-Tetrafluoro-1-propanol → 4-(2,2,3,3-Tetrafluoropropoxy)benzaldehyde

Participants

Reaction Conditions

Reaction Steps

500 ml of dimethylacetamide, 304 g of potassium carbonate, 248 g of 4-fluorobenzaldehyde and 290 g of 2,2,3,3-tetrafluoropropanol are heated for 22.5 hours at 140° C. The reaction mixture is subsequently cooled to 20° C. and filtered. The salt mixture is washed using 300 ml of dimethylacetamide. After the filtrate has been distilled in vacuo at 3 mbar, a bottom temperature of 135° C. and a head temperature of 109° C. to 110° C., 387.95 g of 4-(2,2,3,3-tetrafluoropropoxy) benzaldehyde with a purity (GC) of 98% to 99% are obtained.

Provenance & Evidence