Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | HCID 178509649 | HCID 178509649 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 178483308 | HCID 178483308 | — |
Reaction Steps
2-Chloromethyl-5-(2-cyanophenyl)-1H-benzimidazole (1.31 mole, 0.350 g) was dissolved in 2 ml THF and cooled to 0° C. Dimethylamine (1 ml) was added. The solution was stirred at room temperature for 20 minutes. Ethyl acetate was added. The organic phase was washed with water, dried over sodium sulfate, and concentrated to yield 270 mg of 5-(2-cyanophenyl)-2-dimethylaminomethyl-1H-benzimidazole. (MS)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05569768 |
|---|
| Source dataset | uspto-grants-1996_10 |
|---|
| ORD ID | ord-7715af161a074fcda61cc167cd2f3e98 |
|---|
| Source note | uspto-grants-1996_10 |
|---|
