Cyanogen Bromide → 4-Methylpiperidine-1-carbonitrile

HRID 866329Notes

Reaction equation

[CH3:1][CH:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[N:8]#[C:9]Br.[OH-].[Na+].[Na+].[OH-]>>[CH3:1][CH:2]1[CH2:7][CH2:6][N:5]([C:9]#[N:8])[CH2:4][CH2:3]1

Participants

Reactant 3

HCID 10476Cyanogen Bromide

HCID 693814-Methylpiperidine

HCID 21696466Disodium hydroxide

Product 1

HCID 134426294-Methylpiperidine-1-carbonitrile

Procedure

In the manner given in Example 1, 4-methylpiperidine is treated with cyanogen bromide and aqueous sodium sodium hydroxide to give 4-methyl-1-piperidinecarbonitrile.

Sources & evidence

ORD record: ord-50cf9d99c70047a18b3a7db36c76f152
Source dataset: uspto-grants-1978_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04098791

Reaction notes

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