Thiophenol → HCID 20320706, compound

HRID 866375Notes

Reaction equation

HRID 866375 reaction equation
Br[CH2:2][CH2:3][S:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.C1(S)C=CC=CC=1.[OH:18][C:19]1[CH:29]=[CH:28][C:22]([C:23]([O:25][CH2:26][CH3:27])=[O:24])=[CH:21][CH:20]=1>[OH-].[Na+]>[CH2:26]([O:25][C:23]([C:22]1[CH:28]=[CH:29][C:19]([O:18][CH2:2][CH2:3][S:4][C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=2)=[CH:20][CH:21]=1)=[O:24])[CH3:27]

Participants

5

Reactant 3

HCID 7969ThiophenolHCID 8434EthylparabenHCID 78553((2-Bromoethyl)thio)benzene

Product 1

HCID 20320706HCID 20320706, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

This compound was prepared by the condensation procedure 1A. The required intermediate 2-bromoethylphenyl sulphide may be prepared by condensing 1,2-bromoethane and thiophenol in sodium hydroxide solution, in a manner analogous to that used for preparation of the intermediates for compounds of Example Nos. 62-73, but a method which gives better yields uses the scheme: ##STR25## Condensation with ethyl 4-hydroxybenzoate gave 1-(4-ethoxycarbonylphenoxy)-2-phenylthio ethane, m.p. 50°-51° C.

Workup

  1. customThis compound was prepared by the condensation procedure 1A
  2. custom62-73, but a method which gives better
  3. customyields

Sources & evidence

ORD record
ord-196aa8b03e024a0396e9eac2f4f4ebcf
Source dataset
uspto-grants-1978_07
Patent number
US04098816

Reaction notes

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