Water → HCID 86734035, compound

HRID 866379Notes

Reaction equation

HRID 866379 reaction equation
[CH:1]1([NH2:7])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.ClC([C:11]1[CH:24]=[CH:23][C:14]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[CH:13][CH:12]=1)=O.[OH2:25].N1C=CC=C[CH:27]=1>>[CH:1]1([NH:7][C:27]([CH:16]([O:15][C:14]2[CH:13]=[CH:12][CH:11]=[CH:24][CH:23]=2)[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)=[O:25])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 4

HCID 962WaterHCID 1049PyridineHCID 7965CyclohexylamineHCID 37664104-Benzyloxybenzoylchloride

Product 1

HCID 86734035HCID 86734035, compound

Procedure

A mixture of cyclohexylamine (3.6g.; 0.036 mole) and 4-chlorocarbonylphenoxy phenyl methane (9.04g.; 0.037 mole) in pyridine were heated under reflux for 6hr., then poured into water. The product was extracted into dichloromethane, the organic layer washed with dil. HCl and dried (anhyd. MgSO4). Removal of the drying agent and solvent yielded the crude product which was recrystallised from ethanol M.p. 183°-4°.

Workup

  1. temperaturewere heated
  2. temperatureunder reflux for 6hr
  3. extractionThe product was extracted into dichloromethane
  4. washthe organic layer washed with dil. HCl
  5. dry with materialdried (anhyd. MgSO4)
  6. customRemoval of the drying agent and solvent

Sources & evidence

ORD record
ord-df50c2d210844c839a4d5c286909894f
Source dataset
uspto-grants-1978_07
Patent number
US04098816

Reaction notes

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