Ethylamine → HCID 20321048, compound

HRID 866412Notes

Reaction equation

HRID 866412 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][N:13]=1)[C:7]([O:9]C)=O)([O-:3])=[O:2].[CH2:14]([NH2:16])[CH3:15]>>[CH2:14]([NH:16][C:7](=[O:9])[C:6]1[CH:11]=[CH:12][N:13]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1)[CH3:15]

Participants

3

Reactant 2

HCID 6341EthylamineHCID 13241119Methyl 2-nitropyridine-4-carboxylate

Product 1

HCID 20321048HCID 20321048, compound

Procedure

A mixture of 500 mg. of methyl 2-nitroisonicotinate and 2 ml. of 70% ethylamine was stirred at room temperature for 5 hours. The reaction mixture was extracted with ethyl acetate. The extract was washed with water, dried and then the solvent was distilled off. The crystalline residue was recrystallized from ethyl acetate-n-hexane to give 328 mg. of the desired product.

Workup

  1. additionA mixture of 500 mg
  2. extractionThe reaction mixture was extracted with ethyl acetate
  3. washThe extract was washed with water
  4. customdried
  5. distillationthe solvent was distilled off
  6. customThe crystalline residue was recrystallized from ethyl acetate-n-hexane
  7. customto give 328 mg

Sources & evidence

ORD record
ord-c15ed36903b745a8b67953f7fc5b36c4
Source dataset
uspto-grants-1978_07
Patent number
US04098893

Reaction notes

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