Formaldehyde → HCID 20321117, compound

HRID 866415Notes

Reaction equation

HRID 866415 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][N:12]=1)[C:7]([NH2:9])=[O:8])([O-:3])=[O:2].[CH2:13]=[O:14]>CN(C)C=O>[OH:14][CH2:13][NH:9][C:7](=[O:8])[C:6]1[CH:10]=[CH:11][N:12]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 132411182-Nitropyridine-4-carboxamide

Product 1

HCID 20321117HCID 20321117, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

0.8 g. of 2-nitroisonicotinamide and 2 ml. of 37% formalin were stirred in 2 ml. of dimethylformamide at 110° C for 2 hours. After cooling, to this solution was added ice-water, and the mixture was extracted with ethyl acetate. The extract was washed with water, dried and the solvent was evaporated yielding crystals. The crystals obtained were recrystallized from ethyl acetate to give 0.6 g. of pale yellow crystals.

Workup

  1. temperatureAfter cooling, to this solution
  2. extractionthe mixture was extracted with ethyl acetate
  3. washThe extract was washed with water
  4. customdried
  5. customthe solvent was evaporated
  6. customyielding crystals
  7. customThe crystals obtained
  8. customwere recrystallized from ethyl acetate
  9. customto give 0.6 g

Sources & evidence

ORD record
ord-aa365dc3411f45899158cae72c034f63
Source dataset
uspto-grants-1978_07
Patent number
US04098893

Reaction notes

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