反应详情

N-Cyano-N'-(2-aminoethyl)-N"-[2-((4-methyl-5-imidazolyl)-methylthio)ethyl]guanidine (1.0 g) (see Example 10) and 1N hydrochloric acid (20 ml) were refluxed together for 6 hours. Evaporation and recrystallisation from methanol/isopropanol gave the title compound (0.6 g), m.p. 195°-196° C. (Found: C, 33.1; H, 6.3; N, 22.8; S, 8.8; Cl, 28.8% C10H20N6S.3HCl requires: C, 32.8; H, 6.3; N, 23.0; S, 8.8; Cl, 29.1%).

1. customEvaporation and recrystallisation from methanol/isopropanol