Hydrochloric Acid → HCID 178474909, compound

HRID 866442Notes

Reaction equation

HRID 866442 reaction equation
[CH2:1]([O:3][N:4]=[C:5]([C:29]1[N:30]=[C:31]([NH:34]C(=O)CCl)[S:32][CH:33]=1)[C:6]([NH:8][C@@H:9]1[C:27](=[O:28])[N:11]2[C:12]([C:24]([O-:26])=[O:25])=[C:13]([CH:16]([S:18][C:19]3[NH:23][N:22]=[N:21][N:20]=3)[CH3:17])[CH2:14][S:15][C@H:10]12)=[O:7])[CH3:2].[Na+].NC(N)=S.Cl>O>[CH2:1]([O:3][N:4]=[C:5]([C:29]1[N:30]=[C:31]([NH2:34])[S:32][CH:33]=1)[C:6]([NH:8][C@@H:9]1[C:27](=[O:28])[N:11]2[C:12]([C:24]([OH:26])=[O:25])=[C:13]([CH:16]([S:18][C:19]3[NH:20][N:21]=[N:22][N:23]=3)[CH3:17])[CH2:14][S:15][C@H:10]12)=[O:7])[CH3:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 2723790ThioureaHCID 178474908HCID 178474908, compound

Product 1

HCID 178474909HCID 178474909, compoundYield 73.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of 3.90 g of sodium 7β-{α-ethoxyimino[2-(chloroacetamido)thiazol-4-yl]acetamido}-3-(1-methyl-1 H-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylate in 50 ml of water is added 1.52 g of thiourea. The mixture is stirred at room temperature for 3 hours and adjusted to pH 2.0 with 1N hydrochloric acid. The resulting precipitates are filtered, washed with water and dried to obtain 2.40 g of 7β-[α-ethoxyimino-(2-aminothiazol-4-yl)acetamido]-3-(1-methyl-1H-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid. Yield 73.1%.

Workup

  1. customThe resulting precipitates
  2. filtrationare filtered
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-4d898f50acbb414c8a9b993ded3ac1dc
Source dataset
uspto-grants-1978_07
Patent number
US04098888

Reaction notes

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