反应详情

The title compound is prepared from 3-[3-(2-bromo-ethoxy)-phenyl]-thieno[2,3-d]isoxazole, potassium carbonate, 3-(aminomethyl)pyridine and acetonitrile essentially as described above in example 18 except that the Waters Sep-Pak filtration is eluted with 10% methanol in dichloromethane and the column is eluted using a graded solvent mixture of 2% methanol in dichloromethane, to 6% methanol in dichloromethane. Purity by LC/MS (APCI)=100%, [M+H]+=352.

1. filtrationas described above in example 18 except that the Waters Sep-Pak filtration
2. washis eluted with 10% methanol in dichloromethane
3. washthe column is eluted
4. additiona graded solvent mixture of 2% methanol in dichloromethane