Acetonitrile → (1-Aminoethylidene)bisphosphonic acid
Reaction equation
[C:1](#[N:3])[CH3:2].[P:4]([OH:7])([OH:6])[OH:5]>O>[NH2:3][C:1]([P:4]([OH:7])([OH:6])=[O:5])([P:4]([OH:7])([OH:6])=[O:5])[CH3:2]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 80 °C
Procedure
A mixture of acetonitrile (8.2 g, 0.2 mole), phosphorous acid (32.8 g, 0.4 mole), ISOPAR-M (20 g), and the above wetting agents (0.5 g each) was reacted for 3 hours at 150° C. The mixture was cooled to 80° C and water (50 g) was added. The colorless emulsion broke to give colorless granular 1-amino-1,1-diphosphono ethane, 29 g (71% yield), m.p. 270°-271° C (decomposition).
Workup
- customthe above wetting agents (0.5 g each) was reacted for 3 hours at 150° C
Sources & evidence
- ORD record
- ord-48e528974bc7491291ce6b10ddc849f2
- Source dataset
- uspto-grants-1978_07
- Patent number
- US04100167
Reaction notes
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