Acetonitrile → (1-Aminoethylidene)bisphosphonic acid

Participants

Reaction Conditions

Reaction Steps

A mixture of acetonitrile (8.2 g, 0.2 mole), phosphorous acid (32.8 g, 0.4 mole), ISOPAR-M (20 g), and the above wetting agents (0.5 g each) was reacted for 3 hours at 150° C. The mixture was cooled to 80° C and water (50 g) was added. The colorless emulsion broke to give colorless granular 1-amino-1,1-diphosphono ethane, 29 g (71% yield), m.p. 270°-271° C (decomposition).

Provenance & Evidence