Potassium Carbonate → HCID 20305126, compound

HRID 866578Notes

Reaction equation

HRID 866578 reaction equation
[Cl:1][CH2:2][CH2:3][CH2:4][C:5]1[CH:12]=[CH:11][CH:10]=[CH:9][C:6]=1[CH2:7]Cl.CC(=O)[CH2:15][C:16](=[O:18])[CH3:17].C(=O)([O-])[O-].[K+].[K+]>C(O)C>[Cl:1][CH2:2][CH2:3][CH2:4][C:5]1[CH:12]=[CH:11][CH:10]=[CH:9][C:6]=1[CH2:7][CH2:15][C:16](=[O:18])[CH3:17]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 31261AcetylacetoneHCID 123739901-(Chloromethyl)-2-(3-chloropropyl)benzene

Product 1

HCID 20305126HCID 20305126, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 258 g (1.27 mol) of 2-(3-chloropropyl)benzyl chloride, 2, 140 g (1.4 mol) of 2,4-pentanedione, 6, 175 g (1.27 mol) potassium carbonate, and 700 ml of absolute ethanol was stirred at reflux for 18 hours. Evaporation of the alcohol gave a residue which was partitioned between ether and water. The organic phase was dried over anhydrous MgSO4, concentrated and the residue distilled to give the chloro ketone 7, 218 g, bp 123°-127° C/0.2 mm.

Workup

  1. temperatureat reflux for 18 hours
  2. customEvaporation of the alcohol
  3. customgave a residue which
  4. customwas partitioned between ether and water
  5. dry with materialThe organic phase was dried over anhydrous MgSO4
  6. concentrationconcentrated
  7. distillationthe residue distilled

Sources & evidence

ORD record
ord-d6af99d283904866869838bd44ca42e3
Source dataset
uspto-grants-1978_07
Patent number
US04100185

Reaction notes

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