Ethyl formate → Cyclooctanone, 2-(hydroxymethylene)-

HRID 866673Notes

Reaction equation

[C:1]1(=[O:9])[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:10](OCC)=[O:11]>>[OH:11][CH:10]=[C:2]1[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][C:1]1=[O:9]

Participants

Reactant 2

HCID 8025Ethyl formate

HCID 10403Cyclooctanone

Product 1

HCID 1382068Cyclooctanone, 2-(hydroxymethylene)-

Procedure

As in previous examples, 126 g of cyclooctanone, XXVIc, was reacted with ethyl formate to give 95 g (0.62 mol) of 2-hydroxymethylene-cyclooctanone, XXVIIc, bp 87°-92° C (0.4 mm).

Sources & evidence

ORD record: ord-ad012a1ee4284f9c83a69c28cf66915a
Source dataset: uspto-grants-1978_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04100352

Reaction notes

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