Acetic Acid → HCID 20431454, compound

HRID 866680Notes

Reaction equation

HRID 866680 reaction equation
C(C[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[CH2:12][CH2:13][C:14](=[O:16])[CH3:15])#N.Cl.[C:18]([OH:21])(=[O:20])[CH3:19]>>[C:18]([CH2:19][CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[CH2:12][CH2:13][C:14](=[O:16])[CH3:15])([OH:21])=[O:20]

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 203051084-[2-(3-Oxobutyl)phenyl]butanenitrile

Product 1

HCID 20431454HCID 20431454, compound

Procedure

A solution of 50 g (0.23 mol) of 4-[2-(3-cyanopropyl)phenyl]-2-butanone, 8 in 125 ml glacial acetic acid and 125 ml concentrated HCl was refluxed overnight. The solution was evaporated and the residue diluted with H2O. The precipitate was recrystallized from benzene-petroleum ether to give 42.5 g of the keto acid 9, mp 59°-61° C.

Workup

  1. customThe solution was evaporated
  2. additionthe residue diluted with H2O
  3. customThe precipitate was recrystallized from benzene-petroleum ether

Sources & evidence

ORD record
ord-e718a91a5f3844a6856d9c3ba5d8178f
Source dataset
uspto-grants-1978_07
Patent number
US04100353

Reaction notes

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