2-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline → HCID 20389826, compound

HRID 866759Notes

Reaction equation

HRID 866759 reaction equation
[S:1]1[CH:5]=[C:4]([C:6]([Cl:8])=[O:7])[N:3]=[N:2]1.[NH2:9][C:10]1[C:19]2[C:14](=[CH:15][C:16]([O:22][CH3:23])=[C:17]([O:20][CH3:21])[CH:18]=2)[N:13]=[C:12]([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[N:11]=1>>[ClH:8].[NH2:9][C:10]1[C:19]2[C:14](=[CH:15][C:16]([O:22][CH3:23])=[C:17]([O:20][CH3:21])[CH:18]=2)[N:13]=[C:12]([N:24]2[CH2:29][CH2:28][N:27]([C:6]([C:4]3[N:3]=[N:2][S:1][CH:5]=3)=[O:7])[CH2:26][CH2:25]2)[N:11]=1

Participants

3

Reactant 2

HCID 6162672-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazolineHCID 64854301,2,3-thiadiazole-4-carbonyl chloride

Product 1

HCID 20389826HCID 20389826, compound

Procedure

The title compound was prepared by reacting 1,2,3-thiadiazole-4-carbonyl chloride (D. L. Pain and R. Slack, J. Chem. Soc., 5166 (1965)) and 4-amino-6,7-dimethoxy-2-(1-piperazinyl)quinazoline according to the procedure of Example 1. After crystallization from aqueous ethanol, the title compound melted at 270° C. (dec.).

Workup

  1. customAfter crystallization from aqueous ethanol

Sources & evidence

ORD record
ord-8009f94d3908422688cd140f5ed3b5b6
Source dataset
uspto-grants-1978_07
Patent number
US04101548

Reaction notes

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