反应详情

5-Bromoacetyl salicylamide (515 g) was added to a stirred solution of dibenzylamine (750 g) in ethyl methyl ketone (3.0 l). The mixture was heated at reflux for one hour and the dibenzylamine hydrobromide was filtered and dried. The filtrate was allowed to cool, when the crude product crystallised. This was filtered off, dried, and recrystallised from ethyl acetate, (5 l), to give 5-(N,N-dibenzylglycyl)salicylamide as an off-white solid (336 g), m.p. 168°.

1. temperatureThe mixture was heated
2. temperatureat reflux for one hour
3. filtrationthe dibenzylamine hydrobromide was filtered
4. customdried
5. temperatureto cool
6. customwhen the crude product crystallised
7. filtrationThis was filtered off
8. customdried
9. customrecrystallised from ethyl acetate, (5 l)