Piperidine → HCID 178506598, compound

HRID 866855Notes

Reaction equation

HRID 866855 reaction equation
[IH:1].CS[C:4](=[NH:19])[NH:5][CH:6]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[NH:20]1[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1>CC(O)(C)C>[IH:1].[C:7]1([CH:6]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[NH:5][C:4]([N:20]2[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]2)=[NH:19])[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

Participants

4

Reactant 2

HCID 8082PiperidineHCID 178504030HCID 178504030, compound

Product 1

HCID 178506598HCID 178506598, compound

Reagents, catalysts & solvents 1

HCID 6386tert-ButanolSolvent

Procedure

To a suspension of 9.61 g (0.025 mole) of methyl-N-(diphenylmethyl)-carbamimidothioate hydroiodide in 20 ml of t-BuOH is added 4.26 g (0.05 mole) of piperidine. The mixture is heated under reflux over night. The resulting crystals after cooling in ice, are filtered; mp 200°-213° C. One recrystallization from methanol-t-BuOH yields the pure product, N-(diphenylmethyl)-1-piperidinecarboximidamide monohydroiodide as a white crystalline solid; mp 207°-210° C.

Workup

  1. temperatureThe mixture is heated
  2. temperatureunder reflux over night
  3. temperatureThe resulting crystals after cooling in ice
  4. filtrationare filtered
  5. customOne recrystallization from methanol-t-BuOH

Sources & evidence

ORD record
ord-f854f28d2f474c23ab921b272be5db9d
Source dataset
uspto-grants-1978_07
Patent number
US04101659

Reaction notes

Loading…