反应详情

A mixture of 7.0 g (0.017 mole) of methyl N-(4-chlorobenzhydryl)carbamimidothioate hydroiodide and 2.85 g (0.04 mole) of pyrrolidine in 20 mls of t-BuOH is heated at reflux overnight. The t-BuOH is removed in vacuo and the crude guanidine hydroiodide is crystallized from methanol-ether. The crude product is recrystallized from methanol-t-butanol to yield pure N-(4-chlorobenzhydryl)-1-pyrrolidinecarboximidamide hydroiodide; mp 218°-220° (dec).

1. temperatureis heated
2. temperatureat reflux overnight
3. customThe t-BuOH is removed in vacuo
4. customthe crude guanidine hydroiodide is crystallized from methanol-ether
5. customThe crude product is recrystallized from methanol-t-butanol