反应详情

A solution of 3.0 g. (0.0072 mole) of 2-(p-fluorophenyl)-2-{3-[4-(p-fluoro-α-hydroxybenzyl)piperidino]propyl}-1,3-dioxolane in 5 ml. of chloroform was stirred at room temperature with 25 ml. of 6N hydrochloric acid for 2 hr. The mixture was poured onto crushed ice and an excess of 50% sodium hydroxide solution was added. The free base of the ketone crystallized upon neutralization. The solid which was obtained was recrystallized from benzene-isooctane and gave 1 g. of white solid melting at 144°-146° C.

1. additionThe mixture was poured
2. customonto crushed ice
3. customThe free base of the ketone crystallized upon neutralization
4. customThe solid which was obtained
5. customwas recrystallized from benzene-isooctane
6. customgave 1 g