反应详情

A suspension of 100 g. of sodium 4-acetylbenzenesulfonate in 225 ml. of dimethylformamide is treated with 31 ml. of thionyl chloride and the mixture is stirred at room temperature for 5 minutes, then poured into 1 l. of ice water. The resulting precipitate of 4-acetylbenzenesulfonyl chloride is collected by filtration and washed with ice water. The still-damp product may be used as such without further purification. However, if purification is desired, the following procedure may be used: The product is dissolved in methylene chloride and the solution is dried and evaporated at reduced pressure. Th residual sulfonyl chloride is crystallized from benzene/hexane; m.p. 83°-85° C.

1. additionA suspension of 100 g
2. additionpoured into 1 l
3. filtrationThe resulting precipitate of 4-acetylbenzenesulfonyl chloride is collected by filtration
4. washwashed with ice water
5. customsuch without further purification
6. customHowever, if purification
7. dissolutionThe product is dissolved in methylene chloride
8. customthe solution is dried
9. customevaporated at reduced pressure
10. customTh residual sulfonyl chloride is crystallized from benzene/hexane