Pyridine → HCID 22750329, compound

HRID 866974Notes

Reaction equation

HRID 866974 reaction equation
[NH2:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=1.N1C=CC=CC=1.[C:14]([C:17]1[CH:22]=[CH:21][C:20]([S:23](Cl)(=[O:25])=[O:24])=[CH:19][CH:18]=1)(=[O:16])[CH3:15]>O>[C:14]([C:17]1[CH:18]=[CH:19][C:20]([S:23]([NH:1][C:2]2[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=2)(=[O:25])=[O:24])=[CH:21][CH:22]=1)(=[O:16])[CH3:15]

Participants

5

Reactant 3

HCID 1049PyridineHCID 100093-AminopyridineHCID 2664184-Acetylbenzenesulfonyl chloride

Product 1

HCID 22750329HCID 22750329, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of 23.7 g. of 3-aminopyridine in 400 ml. of pyridine is added 55 g. of 4-acetylbenzenesulfonyl chloride and the resulting solution is stirred at room temperature for 24 hours. The solution is poured into 1 l. of water and the mixture is cooled to 0°-5° C. The precipitate of 4-acetyl-N-(3-pyridyl)benzenesulfonamide is collected by filtration, washed with water and dried; m.p. 182°-183° after crystallization from ethanol.

Workup

  1. additionThe solution is poured into 1 l
  2. filtrationThe precipitate of 4-acetyl-N-(3-pyridyl)benzenesulfonamide is collected by filtration
  3. washwashed with water
  4. customdried
  5. customm.p. 182°-183° after crystallization from ethanol

Sources & evidence

ORD record
ord-112e975d20464980992028f65a93da72
Source dataset
uspto-grants-1978_07
Patent number
US04101661

Reaction notes

Loading…