Dichloromethane → HCID 22750291, compound

HRID 866988Notes

Reaction equation

HRID 866988 reaction equation
[N:1]1([S:6]([C:9]2[CH:14]=[CH:13][C:12]([C:15]3[NH:16][C:17](=[O:24])[C:18](=[CH:22][CH:23]=3)[C:19](O)=O)=[CH:11][CH:10]=2)(=[O:8])=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1.C(Cl)[Cl:26].C[Si](Cl)(C)C.S(Cl)(Cl)=O>C(N(CC)CC)C>[N:1]1([S:6]([C:9]2[CH:14]=[CH:13][C:12]([C:15]3[NH:16][C:17](=[O:24])[C:18](=[CH:22][CH:23]=3)[CH2:19][Cl:26])=[CH:11][CH:10]=2)(=[O:8])=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

6

Reactant 4

HCID 6344DichloromethaneHCID 6397ChlorotrimethylsilaneHCID 24386Thionyl ChlorideHCID 22750311HCID 22750311, compound

Product 1

HCID 22750291HCID 22750291, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

From 4.4 g. of 6-[4-(1-pyrrolidinylsulfonyl)phenyl]-1,2-dihydro-2-oxonicotinic acid in 150 ml. of methylene chloride, 1.6 ml. of triethylamine, 1.45 ml. of trimethylsilyl chloride and 1.7 ml. of thionyl chloride, following the procedure of a) above, there is obtained 6-[4-(1-pyrrolidinylsulfonyl)phenyl]-1,2-dihydro-2-oxonicotinyl chloride.

Sources & evidence

ORD record
ord-ec930b2deafe436b9435db36dbeddfe4
Source dataset
uspto-grants-1978_07
Patent number
US04101661

Reaction notes

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