Dichloromethane → HCID 22750299, compound

HRID 866990Notes

Reaction equation

HRID 866990 reaction equation
[CH2:1]([N:3]([CH2:23][CH3:24])[S:4]([C:7]1[CH:12]=[CH:11][C:10]([C:13]2[NH:14][C:15](=[O:22])[C:16](=[CH:20][CH:21]=2)[C:17](O)=O)=[CH:9][CH:8]=1)(=[O:6])=[O:5])[CH3:2].C(Cl)[Cl:26].C[Si](Cl)(C)C.S(Cl)(Cl)=O>C(N(CC)CC)C>[CH2:1]([N:3]([CH2:23][CH3:24])[S:4]([C:7]1[CH:12]=[CH:11][C:10]([C:13]2[NH:14][C:15](=[O:22])[C:16](=[CH:20][CH:21]=2)[CH2:17][Cl:26])=[CH:9][CH:8]=1)(=[O:6])=[O:5])[CH3:2]

Participants

6

Reactant 4

HCID 6344DichloromethaneHCID 6397ChlorotrimethylsilaneHCID 24386Thionyl ChlorideHCID 22750294HCID 22750294, compound

Product 1

HCID 22750299HCID 22750299, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

From 6.0 g. of 6-[4-(diethylaminosulfonyl)phenyl]-1,2-dihydro-2-oxonicotinic acid in 175 ml. of methylene chloride, 2.4 ml. of triethylamine, 2.2 ml. of trimethylsilyl chloride and 2.5 ml. of thionyl chloride, following the procedure of a) above, there is obtained 6-[4-(diethylaminosulfonyl)phenyl]-1,2-dihydro-2-oxonicotinyl chloride.

Sources & evidence

ORD record
ord-1e6a09007aa0420cba10818261140e22
Source dataset
uspto-grants-1978_07
Patent number
US04101661

Reaction notes

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