Dicyclohexylcarbodiimide → HCID 86735862, compound

HRID 866993Notes

Reaction equation

HRID 866993 reaction equation
OCCNS(C1C=CC(C2NC(=O)C(=CC=2)C(O)=O)=CC=1)(=O)=O.ON1C(=O)CCC1=O.C1(N=C=NC2CCCCC2)CCCCC1.[OH:47][CH2:48][CH2:49][N:50](CCO)[S:51]([C:54]1[CH:59]=[CH:58][C:57]([C:60]2[NH:61][C:62](=[O:76])[C:63](=[CH:74][CH:75]=2)[C:64]([O:66][N:67]2[C:71](=[O:72])[CH2:70][CH2:69][C:68]2=[O:73])=[O:65])=[CH:56][CH:55]=1)(=[O:53])=[O:52]>CN(C)C=O>[OH:47][CH2:48][CH2:49][NH:50][S:51]([C:54]1[CH:59]=[CH:58][C:57]([C:60]2[NH:61][C:62](=[O:76])[C:63](=[CH:74][CH:75]=2)[C:64]([O:66][N:67]2[C:68](=[O:73])[CH2:69][CH2:70][C:71]2=[O:72])=[O:65])=[CH:56][CH:55]=1)(=[O:53])=[O:52]

Participants

6

Reactant 4

HCID 10868DicyclohexylcarbodiimideHCID 80170N-HydroxysuccinimideHCID 22750341HCID 22750341, compoundHCID 86735861HCID 86735861, compound

Product 1

HCID 86735862HCID 86735862, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Procedure

From 3.8 g. of 6-[4-[(2-hydroxyethyl)aminosulfonyl]phenyl]-1,2-dihydro-2-oxonicotinic acid and 1.34 g. of N-hydroxysuccinimide in 60 ml. of dimethylformamide, and 2.56 g. of N,N'-dicyclohexylcarbodiimide in 5 ml. of dimethylformamide, following the procedure of (a) above, there is obtained 6-[4-[(2-hydroxyethyl)aminosulfonyl]phenyl]-1,2-dihydro-2-oxonicotinic acid, 2,5-dioxo-1-pyrrolidinyl ester; m.p. 203.5°-205° C.

Sources & evidence

ORD record
ord-2b8706b697e7453098760f74d18d38cd
Source dataset
uspto-grants-1978_07
Patent number
US04101661

Reaction notes

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