Dicyclohexylcarbodiimide → HCID 86735863, compound

HRID 866994Notes

Reaction equation

HRID 866994 reaction equation
[OH:1][CH2:2][CH:3]1[CH2:8][CH2:7][CH2:6][N:5]([S:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[NH:19][C:20](=[O:27])[C:21](=[CH:25][CH:26]=3)[C:22]([OH:24])=[O:23])=[CH:14][CH:13]=2)(=[O:11])=[O:10])[CH2:4]1.C1(N=C=NC2CCCCC2)CCCCC1.OCCN(CCO)S(C1C=CC(C2NC(=O)C(=CC=2)C(O[N:63]2[C:67](=[O:68])[CH2:66][CH2:65][C:64]2=[O:69])=O)=CC=1)(=O)=O>CN(C)C=O>[OH:1][CH2:2][CH:3]1[CH2:8][CH2:7][CH2:6][N:5]([S:9]([C:12]2[CH:13]=[CH:14][C:15]([C:18]3[NH:19][C:20](=[O:27])[C:21](=[CH:25][CH:26]=3)[C:22]([O:24][N:63]3[C:67](=[O:68])[CH2:66][CH2:65][C:64]3=[O:69])=[O:23])=[CH:16][CH:17]=2)(=[O:11])=[O:10])[CH2:4]1

Participants

5

Reactant 3

HCID 10868DicyclohexylcarbodiimideHCID 22750293HCID 22750293, compoundHCID 86735861HCID 86735861, compound

Product 1

HCID 86735863HCID 86735863, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Procedure

From 5.0 g. of 6-[4-(3-hydroxymethyl-1-piperidinylsulfonyl)phenyl]-1,2-dihydro-2-oxonicotinic acid in 130 ml. of dimethylformamide, and 2.89 g. of N,N'-dicyclohexylcarbodiimide in 10 ml. of dimethylformamide, following the procedure of (a) above, there is obtained 6-[4-(3-hydroxymethyl-1-piperidinylsulfonyl)phenyl]-1,2-dihydro-2-oxonicotinic acid, 2,5-dioxo-1-pyrrolidinyl ester; m.p. 201°-204° C.

Sources & evidence

ORD record
ord-a1b657f771e742b783281ed74c5fb8d9
Source dataset
uspto-grants-1978_07
Patent number
US04101661

Reaction notes

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