Hydrochloric Acid → (4-Bromophenyl)(piperidin-4-yl)methanone--hydrogen chloride (1/1)

HRID 867004Notes

Reaction equation

HRID 867004 reaction equation
C([N:4]1[CH2:9][CH2:8][CH:7]([C:10](=[O:18])[C:11]2[CH:16]=[CH:15][C:14]([Br:17])=[CH:13][CH:12]=2)[CH2:6][CH2:5]1)(=O)C.[ClH:19]>>[ClH:19].[Br:17][C:14]1[CH:13]=[CH:12][C:11]([C:10]([CH:7]2[CH2:8][CH2:9][NH:4][CH2:5][CH2:6]2)=[O:18])=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 13363395HCID 13363395, compound

Product 1

HCID 13180301(4-Bromophenyl)(piperidin-4-yl)methanone--hydrogen chloride (1/1)

Procedure

A sample of 30.9 g of 1-acetyl-4-(4-bromobenzoyl)piperidine is refluxed for 6 hours in 6N HCl, cooled, and the resulting insoluble salt is collected. The salt is recrystallized from an ethanol-ether mixture, then from isopropanol to give off-white crystals, mp 225°-227° C., 4-(4-bromobenzoyl)piperidine hydrochloride.

Workup

  1. temperaturecooled
  2. customthe resulting insoluble salt is collected
  3. customThe salt is recrystallized from an ethanol-ether mixture

Sources & evidence

ORD record
ord-74fa8da622c74b8d91ed7afd30731c7c
Source dataset
uspto-grants-1978_07
Patent number
US04101663

Reaction notes

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