反应详情

The above ether suspension of 5,6-dimethoxy-2-methyl-3-indoleglyoxylyl chloride is added portionwise to a cooled stirring mixture of 4-benzoylpiperidine [Example 9(a)], 150 ml of water, 150 ml of chloroform and 25 g of potassium carbonate. The mixture is stirred for 16 hours at ambient temperature, the organic layer is separated and the solvent is removed, leaving a brown oil which is triturated with cyclohexane and then stirred for 16 hours with ether. A white solid results which is collected, dried and recrystallized thrice from methanol to give the compound, mp 188°-190° C., 4-benzoyl-1-(5,6-dimethoxy-2-methylindol-3-ylglyoxyloyl)piperidine.

1. additionis added portionwise to a cooled
2. stirringThe mixture is stirred for 16 hours at ambient temperature
3. customthe organic layer is separated
4. customthe solvent is removed
5. customleaving a brown oil which
6. customis triturated with cyclohexane
7. stirringstirred for 16 hours with ether
8. customA white solid results which
9. customis collected
10. customdried
11. customrecrystallized thrice from methanol