HCID 19917292, compound → Phthalimide

Participants

Reaction Steps

The resin-bound isopropylcarbodiimide, utilized in the procedures described in Examples 1-3 hereinabove, is prepared as follows: A mixture of 31.8 grams of potassium phthalimide, 25 grams of chloromethylated polystyrene resin (having 2% cross-linking and containing 2.75 milliequivalents of chlorine per gram of resin) and 250 ml. dimethylformamide is stirred at 100° C. for 5.5 hours. The mixture is cooled, filtered, and the insoluble resin product is washed with dimethylformamide, water, and ether, and dried to give 29 grams of resin-bound phthalimide.

Provenance & Evidence