HCID 19917292, compound → Phthalimide

HRID 867053Notes

Reaction equation

HRID 867053 reaction equation
C(N=C=N)(C)C.[C:7]1(=[O:17])[NH:11][C:10](=[O:12])[C:9]2=[CH:13][CH:14]=[CH:15][CH:16]=[C:8]12.[K]>CN(C)C=O>[C:7]1(=[O:17])[NH:11][C:10](=[O:12])[C:9]2=[CH:13][CH:14]=[CH:15][CH:16]=[C:8]12

Participants

4

Reactant 2

HCID 19917292HCID 19917292, compoundHCID 24194345Phthalimide potassium salt

Product 1

HCID 6809PhthalimideYield 115.4%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The resin-bound isopropylcarbodiimide, utilized in the procedures described in Examples 1-3 hereinabove, is prepared as follows: A mixture of 31.8 grams of potassium phthalimide, 25 grams of chloromethylated polystyrene resin (having 2% cross-linking and containing 2.75 milliequivalents of chlorine per gram of resin) and 250 ml. dimethylformamide is stirred at 100° C. for 5.5 hours. The mixture is cooled, filtered, and the insoluble resin product is washed with dimethylformamide, water, and ether, and dried to give 29 grams of resin-bound phthalimide.

Workup

  1. customis prepared
  2. temperatureThe mixture is cooled
  3. filtrationfiltered
  4. washthe insoluble resin product is washed with dimethylformamide, water, and ether
  5. customdried

Sources & evidence

ORD record
ord-61f88bf5baea49ca8236662bc2404041
Source dataset
uspto-grants-1978_07
Patent number
US04102877

Reaction notes

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