Methylamine → HCID 13020127, compound

HRID 867087Notes

Reaction equation

HRID 867087 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([OH:21])([C:15]2[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=2)[CH2:9][C:10](OCC)=[O:11])=[CH:4][CH:3]=1.[CH3:22][NH2:23]>O.C(O)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([OH:21])([C:15]2[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=2)[CH2:9][C:10]([NH:23][CH3:22])=[O:11])=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 6329MethylamineHCID 13020116HCID 13020116, compound

Product 1

HCID 13020127HCID 13020127, compoundYield 79%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

19.4 g (0.05 mole) of ethyl 3-(4-bromophenyl)-3-hydroxy-3-(3-pyridyl)-propanoate, 200 ml of 40% solution of methylamine in water and 30 ml of absolute ethanol was stirred for 24 hours at room temperature. The precipitate was filtered off and recrystallized from isopropyl alcohol, which gave 13.2 g (79%) of the amide. M.p. 188°-191° C. The formula C15H15BrN2O2 was verified through elemental analysis. (The elemental analyses throughout this application were carried out for all elements of the compounds prepared, and are within ± 0.4 percent of the theoretical values if not otherwise stated.) ##STR28##

Workup

  1. filtrationThe precipitate was filtered off
  2. customrecrystallized from isopropyl alcohol, which

Sources & evidence

ORD record
ord-9e66c7a1f54540a79354be56687343cf
Source dataset
uspto-grants-1978_07
Patent number
US04102887

Reaction notes

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