Ammonia → HCID 13020124, compound

HRID 867088Notes

Reaction equation

HRID 867088 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([OH:21])([C:15]2[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=2)[CH2:9][C:10](OCC)=[O:11])=[CH:4][CH:3]=1.[NH3:22]>C(O)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([OH:21])([C:15]2[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=2)[CH2:9][C:10]([NH2:22])=[O:11])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 13020116HCID 13020116, compound

Product 1

HCID 13020124HCID 13020124, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

0.8 g (2.5 mmole) of ethyl 3-(4-bromophenyl)-3-hydroxy-3-(3-pyridyl)-propanoate, 50 ml of aqueous ammonia and 10 ml of absolute ethanol was stirred at room temperature for 24 hours. The white precipitate obtained was collected by filtration. Recrystallization from isopropyl alcohol gave 0.45 g (56%), m.p. 213°-214° C. The formula C14H13BrN2O2 was verified through elemental analysis, C calculated 52.4, found 51.9. ##STR30##

Workup

  1. customThe white precipitate obtained
  2. filtrationwas collected by filtration
  3. customRecrystallization from isopropyl alcohol
  4. customgave 0.45 g (56%), m.p. 213°-214° C

Sources & evidence

ORD record
ord-22d7d7c763f9494fbb0e8f7eca0579fc
Source dataset
uspto-grants-1978_07
Patent number
US04102887

Reaction notes

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