Sodium Hydroxide → HCID 85931568, compound

HRID 867100Notes

Reaction equation

HRID 867100 reaction equation
Cl.[NH2:2][CH2:3][C:4]#[C:5][CH2:6][O:7][CH2:8][C:9]([O:11][CH3:12])=[O:10].[OH-].[Na+]>O>[NH2:2][CH2:3][C:4]#[C:5][CH2:6][O:7][CH2:8][C:9]([O:11][CH3:12])=[O:10]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 85931567HCID 85931567, compound

Product 1

HCID 85931568HCID 85931568, compoundYield 203.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
10 °C

Procedure

Methyl 7-amino-3-oxa-5-heptynoate.hydrochloride (1.0 g., 5.0 millimole) is dissolved in water (25 ml.) providing a clear solution which is cooled to 10° C., treated with 5 N sodium hydroxide (1.2 ml., 6.0 millimole) and immediately extracted with chloroform (3 × 25 ml.). The combined organic extract is dried over magnesium sulfate and filtered. Evaporation (in vacuo at 40° C.) of the filtrate affords the title compound as a pale yellow oil (1.6 g., 100%).

Workup

  1. customproviding a clear solution which
  2. extractionimmediately extracted with chloroform (3 × 25 ml.)
  3. extractionThe combined organic extract
  4. dry with materialis dried over magnesium sulfate
  5. filtrationfiltered
  6. customEvaporation (in vacuo at 40° C.) of the filtrate

Sources & evidence

ORD record
ord-cbda7c634e6f46a6a7f9f33a8cf47702
Source dataset
uspto-grants-1978_07
Patent number
US04102888

Reaction notes

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