Sodium Hydroxide → HCID 85931568, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 7-amino-3-oxa-5-heptynoate.hydrochloride (1.0 g., 5.0 millimole) is dissolved in water (25 ml.) providing a clear solution which is cooled to 10° C., treated with 5 N sodium hydroxide (1.2 ml., 6.0 millimole) and immediately extracted with chloroform (3 × 25 ml.). The combined organic extract is dried over magnesium sulfate and filtered. Evaporation (in vacuo at 40° C.) of the filtrate affords the title compound as a pale yellow oil (1.6 g., 100%).

Provenance & Evidence