1-(1-Acetyloxycyclohexyl)-3-benzyloxy-1-propyne → 3-(1-Acetyloxycyclohexyl)-1-propanol

HRID 867109Notes

Reaction equation

HRID 867109 reaction equation
C(OC(COC1C=CC(F)=CC=1)CCC1N(CCCCCCC(OCC2C=CC=CC=2)=O)C(=O)CS1(=O)=O)C1C=CC=CC=1.[C:45]([O:48][C:49]1([C:55]#[C:56][CH2:57][O:58]CC2C=CC=CC=2)[CH2:54][CH2:53][CH2:52][CH2:51][CH2:50]1)(=[O:47])[CH3:46]>>[C:45]([O:48][C:49]1([CH2:55][CH2:56][CH2:57][OH:58])[CH2:50][CH2:51][CH2:52][CH2:53][CH2:54]1)(=[O:47])[CH3:46]

Participants

3

Reactant 2

HCID 203173761-(1-Acetyloxycyclohexyl)-3-benzyloxy-1-propyneHCID 20317381Benzyl 7-{2-(3-benzyloxy-4-[4-fluorophenoxy]butyl)-1,1,4-trioxo-3-thiazolidinyl}heptanoate

Product 1

HCID 203173843-(1-Acetyloxycyclohexyl)-1-propanol

Procedure

This compound is prepared essentially by the method as described in Example 4, Step E, except that the benzyl 7-{2-(3-benzyloxy-4-[4-fluorophenoxy]butyl)-1,1,4-trioxo-3thiazolidinyl}heptanoate is replaced by 1-(1-Acetyloxycyclohexyl)-3-benzyloxy-1-propyne and no chromatographic purification is needed. The title compound is obtained as an essentially colorless, mobile liquid which is used immediately in Step A-3 below.

Workup

  1. customThis compound is prepared essentially by the method
  2. customno chromatographic purification

Sources & evidence

ORD record
ord-902dbe8e14374e0eb436538d476784f9
Source dataset
uspto-grants-1978_07
Patent number
US04102888

Reaction notes

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