Benzyl 7-{2-(3-benzyloxy-4-[4-fluorophenoxy]butyl)-1,1,4-trioxo-3-thiazolidinyl}heptanoate → 4(S)acetyloxy-1-nonanol

HRID 867115Notes

Reaction equation

HRID 867115 reaction equation
C(OC(COC1C=CC(F)=CC=1)CCC1N(CCCCCCC(OCC2C=CC=CC=2)=O)C(=O)CS1(=O)=O)C1C=CC=CC=1.C([O:52][CH2:53][C:54]#[C:55][C@@H:56]([O:62][C:63](=[O:65])[CH3:64])[CH2:57][CH2:58][CH2:59][CH2:60][CH3:61])C1C=CC=CC=1>>[C:63]([O:62][C@@H:56]([CH2:57][CH2:58][CH2:59][CH2:60][CH3:61])[CH2:55][CH2:54][CH2:53][OH:52])(=[O:65])[CH3:64]

Participants

3

Reactant 2

HCID 20317381Benzyl 7-{2-(3-benzyloxy-4-[4-fluorophenoxy]butyl)-1,1,4-trioxo-3-thiazolidinyl}heptanoateHCID 228002521-benzyloxy-4(S) acetyloxy-2-nonyne

Product 1

HCID 228002554(S)acetyloxy-1-nonanol

Procedure

This compound is prepared essentially by the method as described in Example 5, Step E, except that the benzyl 7-{2-(3-benzyloxy-4-[4-fluorophenoxy]butyl)-1,1,4-trioxo-3-thiazolidinyl}heptanoate is replaced by 1-benzyloxy-4(S) acetyloxy-2-nonyne and no chromatographic purification is needed. The title compound is obtained as a mobile oil which is used immediately in Step A-6 below.

Workup

  1. customThis compound is prepared essentially by the method
  2. customno chromatographic purification

Sources & evidence

ORD record
ord-b0783204581c4619a9a132188c1e307b
Source dataset
uspto-grants-1978_07
Patent number
US04102888

Reaction notes

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