Sodium Bicarbonate → HCID 20384873, compound

HRID 867167Notes

Reaction equation

HRID 867167 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]([C:9]1[CH:16]=[CH:15][C:12]([NH:13][CH3:14])=[CH:11][CH:10]=1)([OH:8])[C:4]([F:7])([F:6])[F:5].Cl[CH2:20][C:21]([N:23]=[C:24]=[S:25])=[O:22].C(=O)(O)[O-].[Na+]>C(COC)OC>[F:1][C:2]([F:17])([F:18])[C:3]([C:9]1[CH:16]=[CH:15][C:12]([N:13]([C:24]2[S:25][CH2:20][C:21](=[O:22])[N:23]=2)[CH3:14])=[CH:11][CH:10]=1)([OH:8])[C:4]([F:6])([F:5])[F:7]

Participants

5

Reactant 3

HCID 516892Sodium BicarbonateHCID 8050151,1,1,3,3,3-Hexafluoro-2-(4-(methylamino)phenyl)propan-2-OLHCID 10997087Acetyl isothiocyanate, chloro-

Product 1

HCID 20384873HCID 20384873, compound

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

To p-(hexafluoro-2-hydroxy-2-propyl)-N-methylaniline (2.73 gm., 0.01 mole) in dimethoxyethane (40 ml), add chloroacetyl isothiocyanate (1.50 gm., 0.011 mole) and stir 1 hr. Pour the reaction mixture onto water and neutralize with sodium bicarbonate. Extract with ether, dry and concentrate. Recrystallize from ether to obtain the product, m.p. 240°-242° C.

Workup

  1. additionPour the reaction mixture onto water
  2. extractionExtract with ether
  3. customdry
  4. concentrationconcentrate
  5. customRecrystallize from ether
  6. customto obtain the product, m.p. 240°-242° C.

Sources & evidence

ORD record
ord-a16e650e96cd4eb09f05903d2bdb9cdb
Source dataset
uspto-grants-1978_07
Patent number
US04103018

Reaction notes

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