Hydrochloric Acid → HCID 12390180, compound

HRID 867172Notes

Reaction equation

HRID 867172 reaction equation
[CH2:1]([C:3]1[CH:4]=[C:5]2[N:10]([C:11]=1[C:12](=[O:30])[C:13]1[CH:18]=[CH:17][C:16]([O:19]S(C3C=CC(C)=CC=3)(=O)=O)=[CH:15][CH:14]=1)[CH:9]=[CH:8][CH:7]=[CH:6]2)[CH3:2].[OH-].[Na+].Cl>C(O)C.O>[CH2:1]([C:3]1[CH:4]=[C:5]2[N:10]([C:11]=1[C:12](=[O:30])[C:13]1[CH:14]=[CH:15][C:16]([OH:19])=[CH:17][CH:18]=1)[CH:9]=[CH:8][CH:7]=[CH:6]2)[CH3:2]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 12390170HCID 12390170, compound

Product 1

HCID 12390180HCID 12390180, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent2×

Procedure

In a 20-liter flask, a suspension of 1050 g (2.5 mols) of 2-ethyl-3-(4-tosyloxy-benzoyl)-indolizine in a solution of 420 g (10.5 mols) of sodium hydroxide dissolved in 8 l of ethanol and 4 l of water was refluxed for 6 hours. At the end of the reaction, the mixture was cooled, diluted with 2.5 l of water, neutralized with hydrochloric acid and the desired product was allowed to crystallize while being stirred. The product was then suction-filtered and dried under vacuum in a drying-oven maintained at 70° C.

Workup

  1. customAt the end of the reaction
  2. temperaturethe mixture was cooled

Sources & evidence

ORD record
ord-f1fac271f5dc4f329961b03f73dabd4a
Source dataset
uspto-grants-1978_07
Patent number
US04103012

Reaction notes

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