Piperidine → HCID 178501344, 화합물

HRID 867315노트

반응식

HRID 867315 반응식
C1CCNCC1.COC(=O)[C@@H]1C[C@@H](OC(=O)N2Cc3c(F)ccc(Br)c3C2)CN1C(=O)OC(C)(C)C>CS(C)=O.O=C(O)C(=O)Nc1c(F)cccc1S(=O)(=O)N1CCCCC1.O=P([O-])([O-])[O-].[Cu][I].[K+].[K+].[K+]>COC(=O)[C@@H]1C[C@@H](OC(=O)N2Cc3c(F)ccc(N4CCCCC4)c3C2)CN1C(=O)OC(C)(C)C

참가 물질

7

반응물 2

HCID 8082PiperidineHCID 1547282651-(tert-Butyl) 2-methyl (2S,4R)-4-((4-bromo-7-fluoroisoindoline-2-carbonyl)oxy)pyrrolidine-1,2-dicarboxylate

생성물 1

HCID 178501344HCID 178501344, 화합물수율 38.4%

시약·촉매·용매 4

HCID 62657Potassium Phosphate, Tribasic시약HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)촉매HCID 1242030262-Fluoro-6-(piperidine-1-sulfonyl)anilino(oxo)acetic acid촉매HCID 679Dimethyl Sulfoxide용매2회

반응 조건

온도
80 °C

후처리

  1. additionThe reaction vials were then cooled to r.t. and diluted with 100 μL of 5% AcOH in DMSO, containing 1,3,5-trimethoxybenzene (0.005M) and were shaken vigorously.
  2. aliquot25 microliter of resulting solution is taken
  3. additionTo the 25 microliter aliquot 700 microliter of MeCN was added prior to UPLC-MS Analysis

출처 및 근거

ORD 기록
ord-4177e93cc9cc405c9e9282e8535fbefd
출처 데이터셋
Figure 4 from Chemistry informer libraries
원본 링크
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