Methylamine → HCID 21289651, compound

HRID 867370Notes

Reaction equation

HRID 867370 reaction equation
[CH3:1][NH2:2].[CH2:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH2:11][CH3:12])[C:6]=1[N:13]1[C:17]([C:18]([OH:20])=[O:19])=[CH:16][N:15]=[CH:14]1)[CH3:4]>C(Cl)Cl>[CH2:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH2:11][CH3:12])[C:6]=1[N:13]1[C:17]([C:18]([O-:20])=[O:19])=[CH:16][N:15]=[CH:14]1)[CH3:4].[CH3:1][NH3+:2]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 13252199HCID 13252199, compound

Product 1

HCID 21289651HCID 21289651, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

5.7 pbw (0.073 mole) of a 40% aqueous solution of methylamine are added dropwise to 15 pbw (0.061 mole) of 1-(2,6-diethylphenyl)imidazole-5-carboxylic acid in 50 pbv of methylene chloride. After 2 hours the mixture is evaporated in vacuo, the residue isstirred with 100 pbv of diethyl ether and filtered off with suction. 15.7 pbw (93% of theory) of methylammonium 1-(2,6-diethylphenyl)imidazole-5-carboxylate, a colorless solid with a m.p. of 110°-113° C., are obtained.

Workup

  1. customAfter 2 hours the mixture is evaporated in vacuo
  2. filtrationfiltered off with suction

Sources & evidence

ORD record
ord-b8ffb337e61f4a72a5f5bde5a139519b
Source dataset
uspto-grants-1988_10
Patent number
US04775406

Reaction notes

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