反应详情

5.7 pbw (0.073 mole) of a 40% aqueous solution of methylamine are added dropwise to 15 pbw (0.061 mole) of 1-(2,6-diethylphenyl)imidazole-5-carboxylic acid in 50 pbv of methylene chloride. After 2 hours the mixture is evaporated in vacuo, the residue isstirred with 100 pbv of diethyl ether and filtered off with suction. 15.7 pbw (93% of theory) of methylammonium 1-(2,6-diethylphenyl)imidazole-5-carboxylate, a colorless solid with a m.p. of 110°-113° C., are obtained.

1. customAfter 2 hours the mixture is evaporated in vacuo
2. filtrationfiltered off with suction