Choline → HCID 21289647, compound

HRID 867371Notes

Reaction equation

HRID 867371 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH2:9][CH3:10])[C:4]=1[N:11]1[C:15]([C:16]([OH:18])=[O:17])=[CH:14][N:13]=[CH:12]1)[CH3:2].[OH:19][CH2:20][CH2:21][N+:22]([CH3:25])([CH3:24])[CH3:23].C1(C)C=CC=CC=1>O>[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH2:9][CH3:10])[C:4]=1[N:11]1[C:15]([C:16]([O-:18])=[O:17])=[CH:14][N:13]=[CH:12]1)[CH3:2].[OH:19][CH2:20][CH2:21][N+:22]([CH3:25])([CH3:24])[CH3:23]

Participants

5

Reactant 3

HCID 305CholineHCID 1140TolueneHCID 13252199HCID 13252199, compound

Product 1

HCID 21289647HCID 21289647, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

25 pbw (0.10 mole) of 1-(2,6-diethylphenyl)imidazole-5-carboxylic acid and 27.0 pbw (0.11 mole) of a 50% aqueous solution of choline are heated in 100 pbv of toluene in a water separator, until the water has been completely removed. The mixture is allowed to cool and is then evaporated in vacuo. 34.5 pbw (97% of theory) of 2-hydroxyethyltrimethylammonium 1-(2,6-diethylphenyl)imidazole-5-carboxylate, a high-viscosity oil, are obtained; identification is carried out by 1H-NMR spectroscopy.

Workup

  1. customhas been completely removed
  2. temperatureto cool
  3. customis then evaporated in vacuo

Sources & evidence

ORD record
ord-94604896fa8a40a8b881c4fac00510ed
Source dataset
uspto-grants-1988_10
Patent number
US04775406

Reaction notes

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