Hydroxide → HCID 13882133, compound

Participants

Reaction Steps

A 14 g. portion of ethyl 1-(3-bromophenyl)-5-cyano-4-pyrazolecarboxylate was hydrolyzed by stirring under reflux in 200 ml. of ethanol with 6 g. ofpotassium hydroxide for 2 hours. The mixture was then poured over ice, acidified and filtered, and the solids were crystallized from ethanol/water and dried at 168° to obtain 10 g. of the desired product, m.p. 215°-217° dec. The product was identified by NMR analysis in CDCl3 /DMSOd6. δ7.06 (s, 1), carboxamide; 7.30-7.64 (m, 4), aromatic; 8.08 (s, 1), pyrazole; 9.10 (s, 1), carboxamide.

Provenance & Evidence