1H-Pyrazole-4-carboxylic acid, 5-(aminocarbonyl)-1-(3-chlorophenyl)- → HCID 178449045, compound

HRID 867388Notes

Reaction equation

HRID 867388 reaction equation
[C:1]([C:4]1[CH:5]=[N:6][N:7]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[CH:13]=2)[C:8]=1[C:9]([NH2:11])=[O:10])([OH:3])=[O:2].[OH-].[CH2:20]([N+:24]([CH2:33][CH2:34][CH2:35][CH3:36])([CH2:29][CH2:30][CH2:31][CH3:32])[CH2:25][CH2:26][CH2:27][CH3:28])[CH2:21][CH2:22][CH3:23]>CO>[CH2:33]([N+:24]([CH2:20][CH2:21][CH2:22][CH3:23])([CH2:25][CH2:26][CH2:27][CH3:28])[CH2:29][CH2:30][CH2:31][CH3:32])[CH2:34][CH2:35][CH3:36].[C:1]([C:4]1[CH:5]=[N:6][N:7]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[CH:13]=2)[C:8]=1[C:9]([NH-:11])=[O:10])([OH:3])=[O:2]

Participants

4

Reactant 2

HCID 1637151H-Pyrazole-4-carboxylic acid, 5-(aminocarbonyl)-1-(3-chlorophenyl)-HCID 2723671Tetrabutylammonium Hydroxide

Product 1

HCID 178449045HCID 178449045, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A 3.26 g. portion of 4-carboxy-1-(3-chlorophenyl)-5-pyrazolecarboxamide wasslurred in 50 ml. of methanol and 12 ml. of 1M tetrabutyl ammonium hydroxide solution was added. The mixture was stirred for 30 minutes, and evaporated to dryness under vacuum to obtain 5.2 g. of product, m.p. 120°-121°. The product was identified by elemental analysis.

Workup

  1. customevaporated to dryness under vacuum
  2. customto obtain 5.2 g

Sources & evidence

ORD record
ord-363ab2a8b5fb415f90b102340ea90d16
Source dataset
uspto-grants-1988_10
Patent number
US04775409

Reaction notes

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