反应详情

A mixture of 9.5 g. of methyl 2-bromo-3-pyrazine carboxylate, 8.2 g. of aniline, 0.5 g. of p-toluene sulfonic acid and 100 ml. of water was stirred and refluxed for two hours. The reaction mixture was poured on ice, extracted with ethyl acetate, the organic extracts were dried and concentrated to yield an oil. The crude residue was eluted on a silica gel column with ethyl acetate-hexane (1:2) yielding the product of this example as a yellow solid, m.p. 72°-75° C.

1. additionA mixture of 9.5 g
2. temperaturerefluxed for two hours
3. additionThe reaction mixture was poured on ice
4. extractionextracted with ethyl acetate
5. customthe organic extracts were dried
6. concentrationconcentrated
7. customto yield an oil
8. washThe crude residue was eluted on a silica gel column with ethyl acetate-hexane (1:2)
9. customyielding the product of this example as a yellow solid, m.p. 72°-75° C.