反应详情

温度

95 °C

To a solution of 6.8 g. of methyl 2-phenylamino-3-pyridine carboxylate in 60 ml. of gamma-butyrolactone there was added, under nitrogen, 13.4 g. of potassium tertiary butoxide. The reaction mixture was heated and stirred for one hour at 95° C., poured on ice and stirred overnight. The mixture was extracted with ether, the aqueous layer acidified with acetic acid to pH 4.5 and the product was collected by filtration. Recrystallization from chloroform, acetone, isopropanol yielded the product of this example as a colorless solid; m.p. 235°-236° C.

1. temperatureThe reaction mixture was heated
2. additionpoured on ice
3. stirringstirred overnight
4. extractionThe mixture was extracted with ether
5. filtrationthe product was collected by filtration
6. customRecrystallization from chloroform, acetone, isopropanol
7. customyielded the product of this example as a colorless solid