4-Hydroxybenzaldehyde → HCID 22840055, compound

HRID 867419Notes

Reaction equation

HRID 867419 reaction equation
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[CH:4][CH:3]=1.[NH2:10][C@@H:11]([C:16]([OH:18])=[O:17])[C:12]([SH:15])([CH3:14])[CH3:13]>CO>[CH3:13][C:12]1([CH3:14])[S:15][CH:6]([C:5]2[CH:8]=[CH:9][C:2]([OH:1])=[CH:3][CH:4]=2)[NH:10][C@H:11]1[C:16]([OH:18])=[O:17]

Participants

4

Reactant 2

HCID 1264-HydroxybenzaldehydeHCID 5852Penicillamine

Product 1

HCID 22840055HCID 22840055, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

1.26 g (10 mmoles) of 4-hydroxybenzaldehyde dissolved in 20 ml of 30% aqueous methanol are added to a solution containing 1.49 g (10 mmoles) of D-penicillamine in 30 ml of 30% methanol. After stirring for 20 hours and recrystallization from ethanol containing water, the title acid is obtained in a yield of 2.4 g (94.8%), m.p.: 207°-209° C., [α]D =+91.3° (c=0.2, dimethylformamide).

Workup

  1. additionare added to a solution
  2. customrecrystallization from ethanol
  3. additioncontaining water

Sources & evidence

ORD record
ord-de81d460f1c5428fb0b7238070f16668
Source dataset
uspto-grants-1988_10
Patent number
US04775675

Reaction notes

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