Piperidine → 1-Methyl-7-(4-oxo-4-piperidin-1-yl-butoxy)-1,3-dihydro-imidazo[4,5-b]quinolin-2-one

HRID 867487Notes

Reaction equation

[CH3:1][N:2]1[C:14]2[C:5](=[N:6][C:7]3[CH:8]=[CH:9][C:10]([O:15][CH2:16][CH2:17][CH2:18][C:19]([OH:21])=O)=[CH:11][C:12]=3[CH:13]=2)[NH:4][C:3]1=[O:22].[NH:23]1[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]1>>[CH3:1][N:2]1[C:14]2[C:5](=[N:6][C:7]3[CH:8]=[CH:9][C:10]([O:15][CH2:16][CH2:17][CH2:18][C:19]([N:23]4[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]4)=[O:21])=[CH:11][C:12]=3[CH:13]=2)[NH:4][C:3]1=[O:22]

Participants

Reactant 2

HCID 8082Piperidine

HCID 142809914-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-butyric acid

Product 1

HCID 142810121-Methyl-7-(4-oxo-4-piperidin-1-yl-butoxy)-1,3-dihydro-imidazo[4,5-b]quinolin-2-one

Procedure

This compound, m.p. 215°-217° C., prepared analogous to Example 15 from 4-[(2,3-dihydro-1-methyl-2-oxo-1H-imidazo[4,5-b]quinolin-7-yl)oxy]butanoic acid and piperidine.

Sources & evidence

ORD record: ord-463258efc2a4499cad99712f2527f4ae
Source dataset: uspto-grants-1988_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04775674

Reaction notes

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